工作内容：教学科研
人才称号：杰出青年科学基金获得者
通讯地址：天津市卫津路94号南开大学元素有机化学研究所
电 话：13820987446
电子邮件：jhxie@nankai.edu.cn
课题组网站：http://zhou.nankai.edu.cn/
研究领域：不对称催化与手性药物和天然产物合成
1990年8月－1992年7月，四川师范学院，学士学位；
1994年9月－1997年7月，南开大学元素有机化学研究所，硕士学位；
2000年9月－2003年7月，南开大学元素有机化学研究所，博士学位；
2007年和2013年两次获得天津市自然科学一等奖（R2）；
2008年获得教育部“新世纪人才计划”支持；
2012年获得“Thieme Chemistry Journals Award”；
2013年得到了国家自然科学杰出青年基金资助；
2019年获得国家自然科学奖一等奖（R2）
已发展了系列羰基化合物的高效不对称催化氢化新反应，实现了多样性手性醇的高效、高选择性不对称合成，并基于多样性手性醇的高效合成新反应和新方法建立和发展了包括加蓝他敏等复杂手性天然产物分子的不对称全合成新策略和新路线，显著提高了手性天然产物的合成效率和选择性。已发表包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Org. Lett.等在内的学术论文110余篇。代表性研究论文如下：
1.Chang-Liang Zhu, Youzhi Xu, Qian-Kun Zhao, Zheng-Yan Huang, Huai-Yu Bin*, Gengping Huang*, Jian-Hua Xie*, Qi-Lin Zhou. Highly Enantioselective Synthesis of Chiral (Hetero)aryl-fused Cyclopentanes Enabled by Malonate-Directed Sequential Olefin Isomerization and Asymmetric Hydrogenation. ACS Catal. 2025, 15, 18738–18749.
2.Fan Yang, Xia-Lin Wang, Feng-Kai Zhao, Huai-Yu Bin, and Jian-Hua Xie*. Enantioselective Total Synthesis of (–)-Vallesamidine Enabled by Asymmetric Hydrogenation and Aza-Wacker Cyclization to Con-struct the Core Spirocyclopentane-1,2'-indoline Structure. Org. Lett. 2025, 27, 5818–5822 (DOI: doi.org/10.1021/acs.orglett.5c01615).
3.Chang-Liang Zhu, Xueyuan Yan, Huai-Yu Bin, Xiong Wu, Zheng-Yan Huang, Pu-Cha Yan*, Genping Huang*, Jian-Hua Xie*, and Qi-Lin Zhou. Enantioselective Synthesis of Chiral 1,4-Dihydroquinolines via Iridium-Catalyzed Asymmetric Partial Hydrogenation of Quinolines. J. Am. Chem. Soc. 2025, 147, 57255735 (DOI:10.1021/jacs.4c13618).
4.Xiong Wu, Hai-Tao Yue, Xiao-Dong Zuo, Xiao-Hui Yang, Pu-Cha Yan*, Jian-Hua Xie*, Qi-Lin Zhou. Kinetic Resolution of Racemic 4-Substituted Chroman-2-ones through Asymmetric Lactone Hydrogenation. CCS Chem. 2024, 6, 2560–2576 (DOI:10.31635/ccschem.024.202303801).
5.Yang Fan, Jian-Hua Xie*, Qi-Lin Zhou.* Highly Efficient Asymmetric Hydrogenation Catalyzed by Iridium Complexes with Tridentate Chiral Spiro Aminophosphine Ligands. Acc. Chem. Res. 2023, 56, 332−349 (https://pubs.acs.org/doi/10.1021/acs.accounts.2c00764).
6.Ying Xiong, Yong-Hong Chen, Tao Li, Jian-Hua Xie*, Qi-Lin Zhou. Enantioselective Total Synthesis of ()-Hamigeran F and Its Rearrangement Product. Org. Lett. 2022, 24, 5161−5165 (https://pubs.acs.org/doi/10.1021/acs.orglett.2c01997).
7.Xue-Song Gu, Ying Xiong, Fan Yang, Na Yu, Pu-Cha Yan*, Jian-Hua Xie*, Qi-Lin Zhou. Enantioselective Hydrogenation toward Chiral 3‑Aryloxy Tetrahydrofurans Enabled by Spiro Ir-PNN Catalysts Containing an Unusual 5‑Substituted Chiral Oxazoline Unit. ACS Catal. 2022, 12, 2206−2211. (https://doi.org/10.1021/acscatal.1c05746).
8.Huai-Yu Bin, Li Cheng, Xiong Wu, Chang-Liang Zhu, Xiao-Hui Yang*, Jian-Hua Xie*, Qi-Lin Zhou, Asymmetric Hydrogenation of Exocyclic γ,δ-Unsaturated β-Ketoesters to Functionalized Chiral Allylic Alcohols via Dynamic Kinetic Resolution. Chem. Sci. 2021, 12, 7793-7799.
9.Lei Cheng, Ming-Ming Li, Biao Wang, Li-Jun Xiao,* Jian-Hua Xie, Qi-Lin Zhou.* Nickel-Catalyzed Hydroalkylation and Hydroalkenylation of 1,3-Dienes with Hydrazones. Chem. Sci. 2019, 10, 10417-10420.
10.Huai-Yu Bin, Ke Wang, Dan Yang, Xiao-Hui Yang, Jian-Hua Xie,* Qi-Lin Zhou. Scalable Enantioselective Total Synthesis of (‐)‐Goniomitine. Angew. Chem., Int. Ed. 2019, 58, 1174-1177.
已培养博士6名，硕士7名
