Xie Jianhua,Master degree,Researcher,Institute of Elemento-organic Chemistry,graduated from Nankai university
Special Talent：National Science Fund for Distinguished Young Scholars
Address：Institute of Elemento-Organic Chemistry Nankai University 94 Wenjin Road, Tianjin 300071Telephone：23508049
Email：jhxie@nankai.edu.cn
Research Group Website：http://zhou.nankai.edu.cn/
Research Interest：
The main emphasis of my research is the discovery and development of new catalytic synthetic methods with particular interest in asymmetric reactions, the asymmetric total synthesis of various biologically active natural products and structural analogues, as well as the design and synthesis of new highly efficient chiral ligands and catalysts for asymmetric reactions.
2007-2008 Postdoctoral Fellow, University of Maryland, USA, (with Prof. Micheal P. Doyle)
2000-2003 Ph.D. (Chemistry), Nankai University, (with Prof. Qi-Lin Zhou)
1994-1997 M.Sc. (Chemistry), Nankai University, (with Prof. Tian-Lin Liu)
1990-1992 B.Sc. (Chemistry), Sichuan Teachers College
2013 Award for Outstanding Young Scientists (National Natural Science Foundation of China)
2012 Thieme Chemistry Journals Award
2008 New Century Excellent Talents Project (Ministry of Education, China)
2007 Tianjin Natural Science Award (The First-Rank)
1. Chang-Liang Zhu, Youzhi Xu, Qian-Kun Zhao, Zheng-Yan Huang, Huai-Yu Bin*, Gengping Huang*, Jian-Hua Xie*, Qi-Lin Zhou. Highly Enantioselective Synthesis of Chiral (Hetero)aryl-fused Cyclopentanes Enabled by Malonate-Directed Sequential Olefin Isomerization and Asymmetric Hydrogenation. ACS Catal.2025, 15, 18738–18749.
2. Fan Yang, Xia-Lin Wang, Feng-Kai Zhao, Huai-Yu Bin, and Jian-Hua Xie*. Enantioselective Total Synthesis of (–)-Vallesamidine Enabled by Asymmetric Hydrogenation and Aza-Wacker Cyclization to Con-struct the Core Spirocyclopentane-1,2'-indoline Structure. Org. Lett.2025, 27, 5818–5822 (DOI: doi.org/10.1021/acs.orglett.5c01615).
3. Chang-Liang Zhu, Xueyuan Yan, Huai-Yu Bin, Xiong Wu, Zheng-Yan Huang, Pu-Cha Yan*, Genping Huang*, Jian-Hua Xie*, and Qi-Lin Zhou. Enantioselective Synthesis of Chiral 1,4-Dihydroquinolines via Iridium-Catalyzed Asymmetric Partial Hydrogenation of Quinolines. J. Am. Chem. Soc.2025, 147, 5725-5735 (DOI:10.1021/jacs.4c13618).
4. Xiong Wu, Hai-Tao Yue, Xiao-Dong Zuo, Xiao-Hui Yang, Pu-Cha Yan*, Jian-Hua Xie*, Qi-Lin Zhou. Kinetic Resolution of Racemic 4-Substituted Chroman-2-ones through Asymmetric Lactone Hydrogenation. CCS Chem.2024, 6, 2560–2576(DOI:10.31635/ccschem.024.202303801).
5.Yang Fan, Jian-Hua Xie*, Qi-Lin Zhou.* Highly Efficient Asymmetric Hydrogenation Catalyzed by Iridium Complexes with Tridentate Chiral Spiro Aminophosphine Ligands. Acc. Chem. Res.2023, 56, 332−349 (https://pubs.acs.org/doi/10.1021/acs.accounts.2c00764).
6. Ying Xiong, Yong-Hong Chen, Tao Li, Jian-Hua Xie*, Qi-Lin Zhou. Enantioselective Total Synthesis of (-)-Hamigeran F and Its Rearrangement Product. Org. Lett.2022, 24, 5161−5165 (https://pubs.acs.org/doi/10.1021/acs.orglett.2c01997).
7. Xue-Song Gu, Ying Xiong, Fan Yang, Na Yu, Pu-Cha Yan*, Jian-Hua Xie*, Qi-Lin Zhou. Enantioselective Hydrogenation toward Chiral 3‑Aryloxy Tetrahydrofurans Enabled by Spiro Ir-PNN Catalysts Containing an Unusual 5‑Substituted Chiral Oxazoline Unit. ACS Catal.2022, 12, 2206−2211. (https://doi.org/10.1021/acscatal.1c05746).
8. Huai-Yu Bin, Li Cheng, Xiong Wu, Chang-Liang Zhu, Xiao-Hui Yang*, Jian-Hua Xie*, Qi-Lin Zhou, Asymmetric Hydrogenation of Exocyclic γ,δ-Unsaturated β-Ketoesters to Functionalized Chiral Allylic Alcohols via Dynamic Kinetic Resolution. Chem. Sci.2021, 12, 7793-7799.
9. Lei Cheng, Ming-Ming Li, Biao Wang, Li-Jun Xiao,* Jian-Hua Xie, Qi-Lin Zhou.* Nickel-Catalyzed Hydroalkylation and Hydroalkenylation of 1,3-Dienes with Hydrazones. Chem. Sci.2019, 10, 10417-10420.
10. Huai-Yu Bin, Ke Wang, Dan Yang, Xiao-Hui Yang, Jian-Hua Xie,* Qi-Lin Zhou. Scalable Enantioselective Total Synthesis of (‐)‐Goniomitine. Angew. Chem., Int. Ed.2019, 58, 1174-1177.
