Luan Yuxin, Doctor, Associate Professor, Institute of Elemento-organic Chemistry, Graduated from Nankai University.

Special Talent:
Address:Room D205, Tiannan Building, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin
Telephone:
Email:yxluan@nankai.edu.cn
Research Group Website:
Research Interest:
1.Organofluorine Chemistry
2.Design and Development of Novel Catalysts
3.Computational Chemistry

2007.9-2011.7, Shandong Agricultural University, Materials Chemistry, Bachelor
2011.9-2014.6, Zhejiang University of Technology, Pesticide Science, Master
2014.7-2015.8, Nankai University, Research Assistant
2015.9-2018.6, Nankai University, Organic Chemistry, Ph.D.
2018.7-2023.9, Nankai University, Assistant Researcher / Postdoctoral Fellow
2018.8-2018.12, Peking University, Visiting Scholar
2023.10-Present, Nankai University, Associate Professor

2018   Outstanding Graduate Student of Nankai University
2017   National Scholarship for Postgraduates; Merit Student Honorary Title of Nankai University 
2016   Wanxiang Excellent Scholarship
2014   Outstanding Graduate of Zhejiang Province
2011   Outstanding Graduate of Shandong Province 
2010   First Prize in the 2nd Shandong Provincial College Students' Chemistry Experiment Skills Competition

The research primarily focuses on catalytic organic synthesis, conducting systematic studies centered on the selectivity control of organic synthesis reactions and achieving a series of innovative outcomes:
1) In terms of site-selectivity control, through the innovative development of novel ligands and reaction modes, the precise site-selective functionalization of various inert C–H bonds has been successfully realized, addressing the challenge of regioselectivity control in the modification of complex molecules;
2) In terms of enantioselectivity control, by designing efficient metal catalytic systems, the efficient asymmetric synthesis of various chiral trifluoromethoxy compounds has been achieved for the first time, providing a crucial synthetic tool for the research and development of chiral fluorine-containing drugs. Relevant research findings have been published in top chemistry journals such as J. Am. Chem. Soc., Angew. Chem. Int. Ed., and Nature Communications. It has led and participated in projects including the National Natural Science Foundation of China, Tianjin Natural Science Foundation, and General Program of the Postdoctoral Science Foundation.

Selected Representative Publications:

10) Yafeng Si, Yuntao Liu, Fan Zhou, Lei Fang, Kang Wu, Yu-Xin Luan,* Li Chen, Pingping Tang.* Cobalt-Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes. Angew. Chem. Int. Ed. 2025, doi.org/10.1002/anie.202501680.
9) Liyan Wang, Yafeng Si, Yu-Xin Luan,* Pingping Tang.* Rhodium-Catalyzed Asymmetric Trifluoromethoxylation of Racemic Allylic Trichloroacetimidates. CCS Chem. 2024, 6, 1885–1894. 
8) Zhijie Deng, Lingduan Meng, Xiao Bing, Shaoxiong Niu, Xiaofeng Zhang, Junqin Peng, Yu-Xin Luan, Li Chen,* Pingping Tang.* Silver-Enabled Dearomative Trifluoromethoxylation of Indoles. J. Am. Chem. Soc. 2024, 146, 2325−2332. 
7) Yangdong Hou, Zhang Zhang, Xinyu Sun, Zheng Yang, Yu-Xin Luan,* Pingping Tang.* Copper-Catalyzed Enantioselective Trifluoromethoxylation of Propargyl Sulfonates. Angew. Chem. Int. Ed. 2023, 62, e202218919. 
6) Tao Zhang, Yu-Xin Luan, Nelson Y. S. Lam, Jiang-Fei Li, Yue Li, Mengchun Ye,* Jin-Quan Yu.* A Directive Ni Catalyst Overrides Conventional Site Selectivity in Pyridine C–H Alkenylation. Nat. Chem. 2021, 13, 1207–1213. 
5) Ge Yin,† Yue Li,† Rong-Hua Wang, Jiang-Fei Li, Xue-Tao Xu,* Yu-Xin Luan,* Mengchun Ye.* Ligand-Controlled Ni(0)–Al(III) Bimetal-Catalyzed C3–H Alkenylation of 2-Pyridones by Reversing Conventional Selectivity. ACS Catal. 2021, 11, 4606–4612. 
4) Rong-Hua Wang, Jiang-Fei Li, Yue Li, Shao-Long Qi, Tao Zhang, Yu-Xin Luan,* Mengchun Ye.* Selective C(sp3)−H Cleavage of Enamides for Synthesis of 2‑Pyridones via Ligand-Enabled Ni−Al Bimetallic Catalysis. ACS Catal. 2021, 11, 858−864. 
3) Wei-Wei Yao, Ran Li, Hao Chen, Ming-Kai Chen, Yu-Xin Luan,* Yi Wang, Zhi-Xiang Yu,* Mengchun Ye.* Ni-catalyzed Hydroaminoalkylation of Alkynes with Amines. Nat. Commun. 2021, 12, 3800–3808. 
2) Yue Li, Feng-Ping Zhang, Rong-Hua Wang, Shao-Long Qi, Yu-Xin Luan,* and Mengchun Ye.* Carbamoyl Fluoride-Enabled Enantioselective Ni-Catalyzed Carbocarbamoylation of Unactivated Alkenes. J. Am. Chem. Soc. 2020, 142, 19844–19849. 
1) Yu-Xin Luan, Tao Zhang, Wei-Wei Yao, Ke Lu, Lu-Yao Kong, Yu-Tong Lin, and Mengchun Ye.* Amide-Ligand-Controlled Highly para-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids. J. Am. Chem. Soc. 2017, 139, 1786–1789.