1990-1994.7: Hunan Normal University，B.S., P. R. China;

1994.9-1997.7: Shanghai Institute of Organic Chemistry, Chinese Academy of Science, M. S., P. R. China;

1998.9-2003.6: University of Notre Dame, Ph. D., USA;

2003.7-2007.12: Scientist I, II and Project Leader at Kosan Biosciences, California, USA;

2008.1- 2020.10: Prof. at College of Pharmacy， Nankai University, Tianjin, P. R. China.

2020.10-Present: Prof. at College of Chemistry， Nankai University, Tianjin, P. R. China.

Research has been conducted on the synthesis and medicinal chemistry of natural products, including lipopeptides, polyketides and terpenoids. Meanwhile, the selectivity and molecular targets of some compounds against cancer stem cells have been identified. Two drug candidates have entered clinical trials, among which ACT001 has advanced to Phase III clinical trials. It has been granted the Breakthrough Therapy Designation by the National Medical Products Administration (NMPA) of China and the Fast Track Designation by the U.S. Food and Drug Administration (FDA), along with other regulatory qualifications. Over 80 academic papers have been published in prestigious journals such as J. Am. Chem. Soc., Angew. Chem. Int. Ed., J. Med. Chem. and Chem. Commun. In addition, a number of invention patents have been authorized in China and overseas, with 3 patents receiving protection in 20 countries and regions worldwide.

15 representative papers

1. Can Liu, Can Liu, Guang-ju Liu, Meng-meng Wang, Yan Jiao, Yuan-jun Sun, Hui Guo, Liang Wang, Ya-xin Lu, Yue Chen*, Ya-hui Ding*, BE-43547A2 exerts hypoxia-selective inhibition on human pancreatic cancer cells through targeting eEF1A1 and disrupting its association with FoxO1, Acta Pharmacol Sin,. 2025 May;46(5):1433-1444.

2. Qing Meng, Jianshuang Guo, Ke Lv, Yang Liu, Jin Zhang, Mingyue Li, Xirui Cheng, Shenghua Chen, Xiaoguang Huo, Quan Zhang*, Yue Chen*, Jing Li*, 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiotadependent manner, Acta Pharmaceutica Sinica B, 2024 May,14(5):2153-2176

3. Sen Zhang, Songming Zhang, Yunlong Fan, Xuhai Zhang, Jing Chen, Chaofan Jin, Sisi Chen, Liang Wang,* Quan Zhang,* and Yue Chen*, Total Synthesis of the Proposed Structure of Neaumycin B, Angew Chem Int Ed. 2023, Dec 18; 62(51):e202313186.

4. Can Liu, Liang Wang,* Yuanjun Sun, Xiuhe Zhao, Tianyang Chen, Xiuwen Su, Hui Guo, Qin Wang, Xiaonan Xi, Yahui Ding,* Yue Chen.*, Probe Synthesis Reveals Eukaryotic Translation  Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A2. Angew. Chem. Int. Ed. 2022, Aug 22; 61(34):e20220695361.

5. Bolin Chen, Qianwei Wu, Dongdong Xu, Xijing Zhang, Yahui Ding, Shiqi Bao, Xuemei Zhang, Liang Wang*, Yue Chen*, A Two-phase Approach to Fusicoccane Synthesis To Uncover a Compound That Reduces Tumourigenesis in Pancreatic Cancer Cells, Angew. Chem. Int. Ed. 2022 May 2; 61(19):e202117476

6. Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng Jiang, Jing Li,* Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, Yang Liu, Qiang Fu, Liang Wang,* Yue Chen.*, Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo 2 Biological Evaluation for Acute Lung Injury. J. Med. Chem. 2022, Feb 24; 65(4):2971-2987

7. Yahui Ding, Qingqing Xue, Shuo Liu, Kai Hu, Da Wang, Tianpeng Wang, Ye Li, Hongyu Guo, Xin Hao, Weizhi Ge, Yan Zhang, Ang Li, Jing Li, * Yue Chen, * Quan Zhang*., Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme In Vivo. J. Med. Chem. 2020, Feb 27;63(4):1597-1611.

8. Junhong Xiang, Yahui Ding,* Jiaxin Li, Xiuhe Zhao, Yuanjun Sun, Da Wang, Liang Wang,* Yue Chen*, Ovatodiolides: Scalable Protection-free Syntheses, Configuration Determination and Biological Evaluation against Hepatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2019, Jul 29;58(31): 10587-10590. 

9. Jing Li, Shanshan Li, Jianshuang Guo, Qiuying Li, Jing Long, Cheng Ma, Yahui Ding, Chunli Yan, Liangwei Li, Zhigang Wu, He Zhu, Keqin Li, Liuqing Wen, Quan Zhang, Qingqing Xue, Caili Zhao, Ning Liu, Ivaylo Ivanov, Ming Luo, Rimo Xi, Haibo Long, Peng Wang, * Yue Chen,* Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia. J. Med. Chem., 2018, May 10;61(9): 4155-4164. (ACS editor’s choice)

10. Yuanjun Sun, Yahui Ding1,Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang*, Yue Chen,* Cyclic Depsipeptide BE-43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells. Angew. Chem. Int. Ed., 2017, Nov 13;56(46): 14627-14631. (Hot Paper, Press Release)

11. Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang*, Guang Yang*, Yue Chen,* Total Syntheses and Biological Activities of Vinylamycin Analogs. J. Med. Chem., 2017, Feb 9;60(3): 1189-1209.

12. Feng Sang,# Yahui Ding,# Jinghan Wang,# Bingxia Sun,# Jianlei Sun,# Yan Geng,# Zhang Zhang, Ke Ding, Ling-Ling Wu, Jian-Wei Liu, Cuigai Bai, Guang Yang,* Quan Zhang,* Lu-Yuan Li,* Yue Chen,* Structure−Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4 Methylester-Rakicidin A. J. Med. Chem., 2016, Feb 11;59(3):1184-1196.

13. Zhong-Jin Yang, Wei-Zhi Ge, Qiu-Ying Li, Yaxin Lu, Jian-Miao Gon, Bei-Jia Kuang, Xiaonan Xi, Haiting Wu, Quan Zhang,* Yue Chen,* Syntheses and Biological Evaluation of Costunolide, Parthenolide and Their Fluorinated Analogues. J. Med. Chem.2015, Sep 10;58(17):7007-7020.

14. Feng Sang, Dongmei Li, Xiaolong Sun, Xianqiang Cao, Liang Wang, Jianlei Sun, Bingxia Sun, Lingling Wu, Guang Yang, Xiaoqian Chu, Jinghan Wang, Changming Dong, Yan Geng, Hong Jiang, Haibo Long, Sijia Chen, Guiyan Wang, Shuzhong Zhang, Quan Zhang, Yue Chen,* Total Synthesis and Determination of the Absolute Configuration of Rakicidin A. J. Am. Chem. Soc., 2014, Nov 5;136(44), 15787-15791.

15. Jing Long, Shan-Feng Zhang, Pan-Pan Wang, Xue-Mei Zhang, Zhong-Jin Yang, Quan Zhang*, Yue Chen,*Total syntheses of parthenolide and its analogs with macrocyclic stereocontrol. J. Med. Chem., 2014, Aug 28;57(16):7098-7112.