Ma Feihe, Ph.D., Associate Professor, Institute of Macromolecular Chemistry, Graduated from Nankai University

Special Talent: Nankai University Hundred Young Talents Program
Address：Room 320, Meng Minwei Building, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin
Telephone:
Email: feihema@nankai.edu.cn
Research Group Website：https://www.x-mol.com/groups/Shi_Linqi
Research Interest: Chaperone - mimetic Materials and Their Biomedical Applications

2008.9-2012.6, School of Chemical Engineering, Tianjin University, Bachelor

2012.9-2015.6, College of Chemistry, Nankai University, Master

2015.9-2018.6,College of Chemistry, Nankai University, Ph.D.

2018.10-2020.11, Department of Biomedical Engineering, Tufts University, USA, Postdoc

2021.3-2024.6, School of Materials Science and Engineering, Tiangong University, Researcher

2024.7- Present, Member of Prof. Shi Linqi's research group, Institute of Macromolecular Chemistry, College of Chemistry, Nankai University. Awarded as Nankai Young Elite, Supervisor of doctoral students, Associate Professor 

Proteins are a core issue in biomaterials, and the chaperone mechanism is an effective method for regulating proteins. Focusing on the research of chaperone-mimetic materials and their biomedical applications, the applicant has published more than 20 papers as the first/corresponding author in journals including Science Advances (Sci. Adv.), Angewandte Chemie International Edition (Angew. Chem. Int. Ed.), and Advanced Materials (Adv. Mater.) in the past five years, with 5 of them published in the recent five years.

Recent Representative Works:

1. Zhang Y. X.; Ma F. H.*; Chen J. J.; Chen Y. J.; Xu L. L.; Li A.; Liu Y.; Ma R. J.; Shi L. Q.*, Controlled Refolding of Denatured IL-12 Using In Situ Antigen-Capturing Nanochaperone Remarkably Reduces the Systemic Toxicity and Enhances Cancer Immunotherapy. Adv. Mater. 2024, 36(19): 2309927.

2. Wu X. H.; Ma F. H*.; Pan B. B.; Zhang Y. L.; Zhu L.; Deng F.; Xu L. L.; Zhao Y.; Yin X.; Niu H. H.; Su X. C.*; Shi L. Q.*, Tailoring a Nanochaperone to Regulate alpha-Synuclein Assembly. Angew. Chem. Int. Ed. 2022, 61(19): e202200192.

3. Ma F. H.^#; Wu X. H.^#; Li A.; Xu L. L.; An Y. L.; Shi L. Q.*, A Balance Between Capture and Release: How Nanochaperones Regulate Refolding of Thermally Denatured Proteins. Angew. Chem. Int. Ed. 2021, 60(19): 10865−10870.

4. Ma F. H.^#; Yang L.^#; Sun Z. R.; Chen J. J.; Rui X. H.; Glass Z.; Xu Q. B.*, Neurotransmitter-derived Lipidoids (NT-lipidoids) for Enhanced Brain Delivery through Intravenous Injection. Sci. Adv. 2020, 6(30): eabb4429.

5. Ma F. H.; Li C.; Liu Y.*; Shi L. Q.*, Mimicking Molecular Chaperones to Regulate Protein Folding. Adv. Mater. 2020, 32(3): 1805945. 

He has supervised 2 master's students to graduation, and assisted in supervising 5 doctoral students and 1 master's student to graduation. The team recruits 2-3 doctoral students and 3-4 master's students annually. With a positive research atmosphere and high student satisfaction, the team warmly welcomes outstanding talents interested in proteins and biomedical polymers to join.