Research is conducted on the biological activities of small organic molecules to guide the rational design of novel bioactive substances and achieve the precise creation of new pharmaceuticals and pesticides. Additionally, biocompatible polymeric drug materials and next-generation of macromolecular and supramolecular nanomedicines with preventive, diagnostic, and therapeutic functions are developed.

Sub-direction:

(1)Research on Drugs：

Precise Creation of New Pharmaceuticals**: It involves developing new targeted drugs against cancer stem cells using natural products as templates and establishing a platform for transforming active ingredients of traditional Chinese medicine into western-style drugs. It also includes generating disease-specific microenvironment-responsive intelligent probes to achieve precise intervention in major diseases, developing high-throughput synthetic methods for novel cyclic peptides with three-dimensional structures to create new drugs, and developing macromolecular drugs such as small nucleic acids, polypeptides, and antibody-drug conjugates (ADCs). Additionally, it focuses on the development of drug molecules and vaccines based on single-cell technology and artificial intelligence.

(2)Research on Pesticides：

Precise Manufacturing, Creation and Effectiv use of Pesticides: It involves developing new theories for the generation of green ecological pesticides, discovering new targets and mechanisms of green ecological pesticides, and realizing the organic integration of pesticide chemistry and biology. It also includes identifying new lead compounds for green pesticides, creating new varieties and novel crystal forms of green pesticides, as well as developing new green manufacturing processes, new formulations and application technologies for green pesticides to reduced pesticide application and enhanced efficacy of green ecological pesticides.

 (3)Research on Biological Detection Reagents：

Novel Development of diagnostic Reagents: Focusing on new methods for quantum dot synthesis and labeling, this involves in situ synthesis of quantum dots in living cells and site-specific labeling, multi-component and multi-color labeling of single viruses, and dynamic tracking of viral infection processes. It also includes designing structural reagents adapted to complex application environments based on quantum dot-encoded nanospheres, extracellular vehicle technology, and small-molecule photonic probes. Additionally, the research addresses the controllability of large-scale reagent preparation and the design of small-molecule photonic probes for clinical application transformation.

 (4)Research on Polymeric Drug Delivery：

Development of Biocompatible Polymeric Drug Materials and Supramolecular Nanomedicines: This involves developing polymeric artificial chaperone systems and verifying their function in regulating the dynamic structure of proteins through three-dimensional chemical space control. It also includes developing novel responsive polymeric nanocarrier technologies to achieve in vivo targeted delivery of therapeutic genes and proteins, as well as developing bioactive polypeptide hydrogel technologies for the development of vaccine adjuvants. Additionally, the research focuses on constructing supramolecular drug delivery systems, and developing nano-immunomodulators and tumor immunotherapies.