A systematic investigation is conducted into the methodologies for the creation of new organic substances. Novel catalysts are developed, and catalyst-based new strategies and methodologies for organic synthesis are established. The mechanisms of organic synthesis are revealed, and the reactivity and selectivity of reactions are regulated, with the aim of achieving green synthesis and precise creation of functional novel organic materials. The development of new synthetic methods, the discovery of new structures, and the progress in large-scale green manufacturing will provide the scientific and material basis for disruptive discoveries in the field of matter, and serve national strategies such as green sustainable development.

Sub-direction:

(1) Research on Asymmetric Synthesis:

The synthesis of chiral substances is closely related to pharmaceuticals, pesticides, fine chemicals, and materials science. Addressing the core scientific issue of efficiency and selectivity in asymmetric catalytic reactions, the research on asymmetric synthesis will be oriented towards the global scientific and technological frontier of chiral catalysis. It aims to achieve precise creation from chiral small molecules to chiral organic supramolecules and then to chiral organic materials, develop novel chiral reagents and catalysts, forge new reactions, methods, concepts, and strategies for the precise creation of chiral substances, and enhance China's original innovation capability in the field of precise chiral substance creation.

(2) Research on Catalytic Synthesis：

In catalytic synthesis reactions, catalysts determine the direction and mode of chemical reactions. According to statistics, more than 90% of industrial processes employ catalysts. The discovery of novel efficient catalysts often brings about revolutionary changes in the synthesis of new substances. This research direction focuses on the catalytic creation of novel organic substances, leveraging technologies such as automated synthesis and high-throughput screening to develop new catalysts and reagents, as well as innovative synthetic strategies and methods. It aims to profoundly reveal the transformation rules of carbon-carbon bonds and carbon-element bonds, achieving precise regulation of the formation, cleavage, and recombination processes of these bonds. This effort will provide the foundation for original innovation and key technical support for the large-scale green production of pharmaceuticals, pesticides, and functional materials in China.

(3) Research on New Reactions：

Develop new-type and high-efficiency catalysts and new reagents, regulate the reactivity and selectivity of reactions, and achieve the precise creation of novel organic substances. Utilize modern synthesis and analysis methods, combined with technologies such as artificial intelligence, to develop high-throughput automated synthesis, screening and detection means for organic compounds, and form a precise and efficient preparation system for new catalysts and reagents. Develop key technologies for catalyst - regulated large - scale molecular synthesis and modern green synthesis technologies, develop revolutionary methods for the synthesis of novel organic substances, put forward new theories for organic molecule creation, significantly improve the synthesis efficiency, and realize the transformation of production methods for pharmaceuticals, pesticides, fine chemicals, and functional materials.