Special Talent：National “Four Young Talents”, Member of the 13th National Committee of the All-China Youth Federation
Address: Room D307, Comprehensive Laboratory Building, Jinnan Campus of Nankai University, Haihe Education Park, Tianjin, P.R. China
Telephone: 022-85358910
Email: guoyu@nankai.edu.cn
Website:
Research Interest:
1.Mechanisms of Viral Recognition and Entry, Transcription and Replication
2.Host-Virus Interaction Mechanisms in Response to Viral Infection
Antibody Drug Development and Reverse Vaccinology Design
2003-2007 Nankai University BS
2007-2012 Nankai University Ph D
2012-2015 Nankai University Lecturer
2015-2020 Nankai University Associate Professor
2017-2018 Stanford University Visiting Scholar
2020-2021 Nankai University Professor
2020-Present State Key Laboratory of Medicinal Chemical Biology Principal Investigator
2021.07-Present Nankai University Professor
2020, National "Upward and Virtuous" Outstanding Youth
2020, Typical Figure of the Young Talent Support Program of China Association for Science and Technology (CAST)
2020, National Silver Award, National "Challenge Cup" College Students' Entrepreneurship Plan Competition (Instructor)
2019, National Bronze Award, China "Internet Plus" College Students' Innovation and Entrepreneurship Competition (Instructor)
Representative results
1.A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nature Communications, 2021；
2.Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes, PLOS Biology, 2021；
3.Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine, Protein Cell, 2021；
4.Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot, and Mouth Disease，Journal of Medicinal Chemistry, 2020；
5.Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly, Protein Cell, 2020；
6.Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding, Protein Cell, 2020；
7.Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design, Journal of Virology, 2020
