Dong Jiantong
Ph.D., Researcher
Jiantong Dong, Doctor degree, Researcher, Institute of Research Center for Analytical Sciences, graduated from Peking University.
Special Talent：National Outstanding Young Scholar
Address：Room 503, Building B, Frontier Interdisciplinary Building, Jinnan Campus, Nankai University, No. 38 Tongyan Road, Haihe Education Park, Jinnan District, Tianjin, P. R. China.
Telephone：
Email：jtdong2025@nankai.edu.cn
Research Group Website：https://www.x-mol.com/groups/dong_jiantong
Research Interest：
1. Microfluidic chip-based analysis of pathogens, exosomes and organoids
2. Biomimetic, sensing and bioimaging systems based on dynamic nucleic acid assembly
3. Precision medical analysis using nanomaterial‑mediated targeted delivery of bioprobes
History：
2010–2014 Shandong University, B.S. in Chemistry (National Base Program)
2014–2021 Peking University, Ph.D. in Analytical Chemistry2017–2019 University of California, Los Angeles (UCLA), USA, Joint Ph.D. Training2021–2025 The Hebrew University of Jerusalem, Israel, Postdoctoral Research Fellow2025–Present Professor / Principal Investigator, College of Chemistry, Nankai UniversityHonors and Awards
1. National Outstanding Young Scholar (Overseas Program), 2025
2. Excellent Young Scholar Award, 1st Academic Conference on Biomimetic Materials Chemistry, Chinese Chemical Society (CCS), 2025
3. Outstanding Graduate of Beijing Municipal Universities, 2021
Scientific Achievements & Selected Publications
In recent years, she has published or accepted more than 20 SCI papers as the first/corresponding author (including co‑author) in the fields of biomimetic microfluidic chip analysis, dynamic nucleic acid sensing and imaging, and biomedical detection. These publications include 1 in Nature Chemistry, 4 in Journal of the American Chemical Society, 2 in Science Advances, 2 in Angewandte Chemie International Edition, 1 in Nature Communications, 1 in Advanced Materials, 1 in Chemical Society Reviews, 2 in ACS Nano, 1 in Advanced Functional Materials, and 1 in Analytical Chemistry, among others.
1. J. Dong, I. Willner*, Synthetic Dynamic Transcription Frameworks and Their Applications, Nat. Chem., 2026, in press, DOI: 10.1038/s41557-025-02046-w.
2. J. Dong, F. Xia*, F. Huang*, and I. Willner*, Dynamic Transcription Machineries in Protocells, J. Am. Chem. Soc., 2025, 147, 22, 18359–18373.
3. J. Dong, I. Willner*, Photochemically Triggered, Transient, and Oscillatory Transcription Machineries Guide Temporal Modulation of Fibrinogenesis, J. Am. Chem. Soc., 2025, 147, 2216–2227.
4. J. Dong, I. Willner*, Transient Transcription Machineries Modulate Dynamic Functions of G-Quadruplexes: Temporal Regulation of Biocatalytic Circuits, Gene Replication and Transcription, Angew. Chem. Int. Ed., 2023, 62, e202307898.
5. J. Dong, M. P. O’ Hagan, and I. Willner*, Switchable and Dynamic G-Quadruplexes and Their Applications, Chem. Soc. Rev., 2022, 51, 7631–7661.
6. J. Dong, I. Willner*, Dynamic Transcription Machineries Guide the Synthesis of Temporally Operating DNAzymes, Gated and Cascaded DNAzyme Catalysis, ACS Nano, 2023, 17, 687–696.
7. J. Dong, Y. Ouyang, J. Wang, M. P. O’ Hagan, and I. Willner*, Assembly of Dynamic Gated and Cascaded Transient DNAzyme Networks, ACS Nano, 2022, 16, 6153.
8. J. Dong, Y. J. Jan, J. Cheng, R. Y. Zhang, M. Meng, M. Smalley, P.-J. Chen, X. Tang, P. Tseng, L. Bao, T.-Y. Huang, D. Zhou, Y. Liu, X. Chai, H. Zhang, A. Zhou, V. G. Agopian, E. M. Posadas, J.-J. Shyue, S. J. Jonas, P. S. Weiss, M. Li*, G. Zheng*, H.-h. Yu*, M. Zhao*, H.-R. Tseng*, and Y. Zhu*, Covalent Chemistry on Nanostructured Substrates Enables Noninvasive Quantification of Gene Rearrangements in Circulating Tumor Cells, Sci. Adv., 2019, 5, eaav9186.
9. J. Dong#, J.-F. Chen#, M. Smalley, M. Zhao, Z. Ke*, Y. Zhu*, and H.-R. Tseng*, Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications, Adv. Mater., 2020, 32, 1903663.
10. J. Dong, R. Y. Zhang, N. Sun, J. Hu, M. D. Smalley, A. Zhou, Y. Hua, W. Rothermich, M. Chen, J. Chen, J. Ye, P.-C. Teng, D. Qi, J. A. Toretsky, J. S. Tomlinson, M. Li, P. S. Weiss, S. J. Jonas, N. Federman, L. Wu, M. Zhao, H.-R. Tseng and Y. Zhu, Sarcoma-Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies, Adv. Funct. Mater., 2020, 30, 2070322.
11. M. Ji, J. Dong*, Z. Ye, J. Kang, G. Han, X. Hong, Y, Wei, X, Chen*, W. Sun*, and D. Liu*, Endogenous HClO-Gated Cascade MicroRNA Imaging for Precise Diagnosis of Atherosclerosis In Vivo, J. Am. Chem. Soc., 2025, 147, 7113–7126. (*co-corresponding author)
12. X. Wang, J. Dong*, J. Kang, X. Chen, X. Hong, J. Chen, W. Du, H. Cai, and D. Liu*, Self-Adaptive Release of Stem Cell-Derived Exosomes from a Multifunctional Hydrogel for Accelerating MRSA-Infected Diabetic Wound Repair, J. Am. Chem. Soc., 2025, 147, 16362–16378. (*co-corresponding author)
13. H. Liu#, J. Dong#, R. Wu#, J. Dai, X. Lou, F. Xia, I. Willner and F. Huang, Light-Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression, Angew. Chem. Int. Ed., 2025, e202502892. (#co-first author)
14. H. Liu#, J. Dong#, Z. Duan, F. Xia, I. Willner and F. Huang, Light-activated CRISPR-Cas12a for amplified imaging of microRNA in cell cycle phases at single-cell levels, Sci. Adv., 2024, 10, eadp6166. (#co-first author)
15. Y. Afshar#, J. Dong#, P. Zhao, L. Li, S. Wang, R. Y. Zhang, C. Zhang, O. Yin, C. S. Han, B. D. Einerson, T. L. Gonzalez, H. Zhang, A. Zhou, Z. Yang, S.-J. Chou, N. Sun, J. Cheng, H. Zhu, J. Wang, T. X. Zhang, Y.-T. Lee, J. J. Wang, P.-C. Teng, P. Yang, D. Qi, M. Zhao, M.-S. Sim, R. Zhe, J. D. Goldstein, J. Williams, X. Wang, Q. Zhang, L. D. Platt, C. Zou, M. D. Pisarska, H.-R. Tseng and Y. Zhu, Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders, Nat. Commun., 2021, 12, 4408. (#co-first author)
Professional Cultivation
Each year, the group recruits 2–3 master’s students and 2 doctoral students, including recommended graduate students and direct Ph.D. candidates. Postdoctoral positions are long-term available. We maintain close collaborations with prestigious universities in the United States, Canada, the United Kingdom, Israel and other countries, and provide recommendations for overseas study opportunities.
